Mesothelioma is a rare and fatal form of cancer which affect the lining of the lungs (the pleura), the abdominal cavity (the peritoneum) or the lining around the heart (the pericardium). Lung mesothelioma is caused by exposure to mineral fibers (such as asbestos).
Mesothelioma lawyers raises the relationship between exposure to asbestos and the development of peritoneal mesothelioma. Some individuals there were presentations on their work, while others were exposed secondarily by family members who, unwittingly, have reduced fiber to the home of their work in their clothes or their hair or on their skin.
The occurrence of this disease, sometimes referred to as “asbestos cancer,” this fiber is the main risk factor known for this type of cancer, is not indicative of a minimum threshold of exposure and medical treatment a limited impact on the life expectancy of patients. According to best mesothelioma lawyers, the first signs found on physical examination are chest pain, often associated with shortness of breath and recurrent pleural effusion, hemorrhage in general. The latency between first exposure and development of mesothelioma is rarely less than 20 years, often on the order of 30 to 40 years or more. There appears to be no threshold of exposure value associated with a risk of occurrence.
The mesothelium is composed of a single thin layer of cuboidal cells forming an epithelium lining the serous body cavities including the peritoneum, pericardium, and pleura to form a virtual cavity. The deposition of mineral fibers in the lung parenchyma can result in penetration into the visceral pleura from where the fiber can then collect the pleural surface and thus lead to the development of malignant mesothelial plaques. Frédéric Gaspoz notes that the process leading to the development of peritoneal mesothelioma is not yet known. It was suggested that asbestos fibers from the lung could be transported to the abdomen and associated organs via the lymphatic system. Also, the inorganic fibers can be deposited in the
It was shown that the contamination of the pleura by asbestos or other mineral fibers, can induce carcinogenesis. The long, thin asbestos fibers (blue asbestos, amphibole) are more effective than “feathery fibers” carcinogenic chrysotile (or white asbestos). In rats developing mesothelioma was caused by intra-pleural inoculation of phosphorylated chrysotile fibers. It was suggested that in humans, transport of fibers to the pleura is the critical stage in the pathogenesis of mesothelioma. This hypothesis is supported by the influx observed a significant number of macrophages and other cells of the immune system to localized lesions caused by asbestos fibers accumulated in the pleural and peritoneal cavities of rats.
Generally, it is believed that asbestos fibers exert their carcinogenic effects using direct physical interactions with cells of the mesothelium in conjunction with indirect effects with interaction with inflammatory cells such as macrophages. According to Frédéric Gaspoz, studies involving intrapleural or intraperitoneal inoculation of different types of asbestos fibers in rats and mice have shown that the long, thin fibers are responsible for a higher incidence of mesothelioma and the short fibers cells that engulf and store the longer fibers more efficiently than short fibers. Similarly, incubation of Syrian hamster cells with glass fiber with an average length of 9.5μm was caused cell transformation with an identical speed to that of crocidolite.
Occupational exposure to asbestos is the main risk factor for mesothelioma. An asbestos exposure past exists in almost all reported cases. However, mesothelioma has been reported in a few cases of individuals without any known exposure to asbestos.
Asbestos is the name of a mineral that naturally occur in the form of an agglomerate of hard and flexible fibers that can be separated into the thin son and be woven. Asbestos was widely used in many industrial products, including cement, brake linings, roof shingles, flooring, textiles, and insulation products. If tiny asbestos particles float in the air, especially during the manufacturing process, they can be inhaled or swallowed and cause serious health problems. Mesothelioma attorneys further explain that exposure to asbestos increases the risk of lung cancer, asbestosis causes pulmonary fibrosis (chronic non-cancer disease) and other cancers, such as tumors of the larynx and kidney. For one person the combination of smoking and asbestos exposure significantly increases the risk of developing cancer of the upper airway or bronchial carcinoma. The Kent brand has used asbestos in its filters for cigarettes for some of its early years of production in the 1950s, and some cases of mesothelioma have resulted.